Novak Djokovic spent just 40 minutes on Centre Court leading 6-3, 2-0 before Martin Klizan had to retire suffering with a recurring calf injury at SW19.
Djokovic booked his place in the last four at the Aegon International with a 6-2, 7-6(9) victory over Young to set up a clash with Daniil Medvedev.
Novak Djokovic secured his first victory at Eastbourne with a 6-4, 6-3 win over Vasek Pospisil in their second round match held over from Tuesday.
Thiem stunned Nadal in straight sets to set up a semifinal clash with either Djokovic or del Potro, who will have to come back on Saturday in Rome.
Welcome to the first edition of the ATP Weekly Ledger in 2017, recapping ATP winners alongside the notable results from the previous week's action and analysis of the newly released rankings.
The defending champion came through a thrilling contest, coming back from a set and a break down and five match points down in the second set tiebreak to win 4-6, 7-6(7), 6-3.
The defending champion needed just one hour and 55 minutes and only dropped seven games as he booked his place in the quarterfinals.
The world number one had little trouble coming through his opening match in an entertaining clash against a Brit.